Journal: Heritage Science

Article Title: The role of smalt in complex pigment mixtures in Rembrandt’s Homer 1663: combining MA-XRF imaging, microanalysis, paint reconstructions and OCT

doi: 10.1186/s40494-020-00429-5

Figure Lengend Snippet: Fig. 2 Rembrandt van Rijn, Homer, 1663, oil on canvas (fragment), 107 × 82 cm, Mauritshuis, The Hague (inv. nr. Mh584). Visible light image (a), and corresponding MA-XRF maps: cobalt (b), nickel (c), lead (d), tin (e), copper (f), iron (g), manganese (h), and calcium (i)

Article Snippet: Macroscopic X‐ray fluorescence imaging (MA‐XRF) MA-XRF maps were collected using the Bruker M6 Jetstream prototype [23].

Techniques:

Journal: Heritage Science

Article Title: The role of smalt in complex pigment mixtures in Rembrandt’s Homer 1663: combining MA-XRF imaging, microanalysis, paint reconstructions and OCT

doi: 10.1186/s40494-020-00429-5

Figure Lengend Snippet: Fig. 3 T-SNE cluster analyses of the MA-XRF data showing the 18 clusters (a–d) as color projections on top of the Pb-L map (left), together with their spectral line intensities (middle), and tSNE plots (right)

Article Snippet: Macroscopic X‐ray fluorescence imaging (MA‐XRF) MA-XRF maps were collected using the Bruker M6 Jetstream prototype [23].

Techniques:

Journal: Heritage Science

Article Title: The role of smalt in complex pigment mixtures in Rembrandt’s Homer 1663: combining MA-XRF imaging, microanalysis, paint reconstructions and OCT

doi: 10.1186/s40494-020-00429-5

Figure Lengend Snippet: Fig. 4 MA-XRF Co:Ni scatter plot (left). The pixels of the cobalt distribution map are colored green (relatively higher Ni content) and red (lower Ni content) (right)

Article Snippet: Macroscopic X‐ray fluorescence imaging (MA‐XRF) MA-XRF maps were collected using the Bruker M6 Jetstream prototype [23].

Techniques:

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Article Title: Predicting Therapeutic Antibody Delivery into Human Head and Neck Cancers

doi: 10.1158/1078-0432.CCR-19-3717

Figure Lengend Snippet: Comparison between primary tumor and lymph node metastasis showed their differential uptake was related to tumor size. (A) The ratio of positive NIR fluorescence area normalized by EGFR positive tumor area for the micrometastasis and primary tumors were significantly higher than that in the macrometastasis. (B) The EGFR expression showed no significant difference between the primary and metastasis. (C) The vessel area fraction for micrometastasis and primary tumors were significantly higher than that in macrometastasis. (D) Collagen area fraction was significantly higher in primary tumor than that in metastasis. (E) α-SMA area fraction showed no difference between primary and metastasis. (ns: P>0.05, *P<0.05, **P<0.01, ***P<0.001, Mann-Whitney test, error bar means standard error). (F-H) Representative images of the primary tumor, macrometasis, and micrometastasis from the same patient showed heterogeneous NIR fluorescence microscopic image (green: NIR, blue: DAPI nuclei) despite homogenous EGFR expression, which may be due to the differential expression of vessel and collagen in these tumor regions. (Scale bar: 100 μm)

Article Snippet: Macroscopic imaging: Primary tumor specimens were formalin-fixed overnight and sectioned into 5 mm sections that were imaged with a macroscopic NIR fluorescence imager (the Pearl Trilogy imaging system, LI-COR Biosciences, Lincoln, NE USA).

Techniques: Fluorescence, Expressing, MANN-WHITNEY